Akt-pS473, Phosphorylation Site Specific (Concentrate)

This monoclonal rabbit antibody labels activated Akt protein that is phosphorylated at serine residue 473. Akt, also known as protein kinase B (PKB) or Rac-α, is a serine/threonine protein kinase that functions as an important regulator of various cell processes including apoptosis, proliferation, differentiation and metabolism. Akt is a critical downstream effector of PI3-kinase (PI-3K), which mediates signal transduction initiated by a variety of stimuli including hormones, growth factors and cytokines. PI-3K activates Akt through a second messenger, which results in phosphorylation of Akt at threonine 308 and at serine 473 by upstream protein kinases. Activated Akt phosphorylates a number of protein substrates including BAD, caspase-9, forkhead transcription factors, GSK-3-α-ß, CREB and mTOR/FRAP.