uPAR (Concentrate)

Reacts with urokinase-type plasminogen activator receptor (uPAR), also designated CD87. uPAR is part of the plasminogen activator system, which is involved in both early phases of carcinogenesis as well as cancer invasion and metastasis (1, 2). In normal tissue, the antibody labels a subpopulation of macrophages and neutrophils in tonsil and breast tissue as well as in the lamina propria of the intestine. The antibody labels a subpopulation of tumor-associated stromal macrophages and is a useful aid for classification of invasive colon and breast carcinomas as well neoplastic glands of colon adenocarcinomas.