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Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor, which is involved in proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. Results aid in the classification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids.